-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, Kn7lEnkTd9QOcoA5jEwVi4WqNbmGSmAYfbBH9IuvWL0RrIwjR8sK0afb8Igeh8aT qMfloNnRSS4+U9MkiscNMQ== 0000950116-99-000250.txt : 19990217 0000950116-99-000250.hdr.sgml : 19990217 ACCESSION NUMBER: 0000950116-99-000250 CONFORMED SUBMISSION TYPE: SC 13G PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 19990216 GROUP MEMBERS: HAROLD R. WERNER GROUP MEMBERS: HEALTHCARE PARTNERS V, L.P. GROUP MEMBERS: HEALTHCARE VENTURES I LP GROUP MEMBERS: HEALTHCARE VENTURES V, L.P. GROUP MEMBERS: JAMES H. CAVANAUGH, PH.D. GROUP MEMBERS: JOHN W. LITTLECHILD GROUP MEMBERS: MARK LESCHLY GROUP MEMBERS: WILLIAM CROUSE SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: MAGAININ PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000880431 STANDARD INDUSTRIAL CLASSIFICATION: BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836] IRS NUMBER: 133445668 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G SEC ACT: SEC FILE NUMBER: 005-42170 FILM NUMBER: 99541533 BUSINESS ADDRESS: STREET 1: 5110 CAMPUS DR CITY: PLYMOUTH MEETING STATE: PA ZIP: 19462 BUSINESS PHONE: 6109415231 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: HEALTHCARE VENTURES I LP CENTRAL INDEX KEY: 0001013461 STANDARD INDUSTRIAL CLASSIFICATION: SERVICES-OFFICES & CLINICS OF DOCTORS OF MEDICINE [8011] IRS NUMBER: 133281537 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G BUSINESS ADDRESS: STREET 1: TWIN TOWERS AT METRO PARK STREET 2: 379 THORNALL AVENUE CITY: EDISON STATE: NJ ZIP: 08837 BUSINESS PHONE: 9089064613 MAIL ADDRESS: STREET 1: TWIN TOWERS AT METRO STREET 2: 379 THORNALL AVENUE CITY: EDISON STATE: NJ ZIP: 08837 SC 13G 1 SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. )(1) MAGAININ PHARMACEUTICALS, INC. - -------------------------------------------------------------------------------- (Name of Issuer) Common Stock $.002 par value - -------------------------------------------------------------------------------- (Title of Class of Securities) 559036108 - -------------------------------------------------------------------------------- (CUSIP Number) December 31, 1998 - -------------------------------------------------------------------------------- (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1 (b) [ ] Rule 13d-1 (c) [X] Rule 13d-1 (d) - ---------- (1) The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). (Continued on following page(s)) Page 1 of 14 Pages - ------------------------------- ----------------------------- CUSIP NO. 559036108 13G Page 2 of 14 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON HealthCare Ventures V, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 2,073,500 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 2,073,500 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,073,500 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 9.3% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! -2- - ------------------------------- ----------------------------- CUSIP NO. 559036108 13G Page 3 of 14 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON HealthCare Partners V, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 2,073,500 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 2,073,500 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,073,500 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 9.3% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! -3- - ------------------------------- ----------------------------- CUSIP NO. 559036108 13G Page 4 of 14 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON James H. Cavanaugh, Ph.D. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER 2,321 ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 2,214,716 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH 2,321 ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 2,214,716 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,217,037 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 9.9% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! -4- - ------------------------------- ----------------------------- CUSIP NO. 559036108 13G Page 5 of 14 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON Harold R. Werner - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER 4,859 ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 2,214,716 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH 4,859 ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 2,214,716 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,219,575 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 9.9% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! -5- - ------------------------------- ----------------------------- CUSIP NO. 559036108 13G Page 6 of 14 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON William Crouse - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 2,214,716 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 2,214,716 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,214,716 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 9.9% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! -6- - ------------------------------- ----------------------------- CUSIP NO. 559036108 13G Page 7 of 14 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON John W. Littlechild - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 2,214,716 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 2,214,716 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,214,716 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 9.9% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! -7- - ------------------------------- ----------------------------- CUSIP NO. 559036108 13G Page 8 of 14 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON Mark Leschly - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 2,073,500 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 2,073,500 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,073,500 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 9.3% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! -8- Page 9 of 14 Item 1. (a) Name of Issuer: Magainin Pharmaceuticals, Inc. (b) Address of Issuer's Principal Executive Offices: 5110 Campus Drive Plymouth Meeting, Pennsylvania 19462 Item 2. (a) Name of Person Filing: HealthCare Ventures V, L.P. ("HCV V"), HealthCare Partners V, L.P. ("HCP V"), Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly. See attached Exhibit A which is a copy of their agreement in writing to file this statement on behalf of each of them.(1) (b) Address of Principal Business Office or, if none, Residence: The business address for HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner and Crouse is 44 Nassau Street, Princeton, New Jersey 08542. The business address for Messrs. Littlechild and Leschly is One Kendall Square, Building 300, Cambridge, Massachusetts 02139. (c) Citizenship: HCV V and HCP V are limited partnerships organized under the laws of the State of Delaware. Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are each United States citizens. (d) Title of Class of Securities: Common Stock, par value $.002 ("Shares"). (e) CUSIP Number: 559036108 - -------- (1) Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are general partners of HCP V, which is the general partner of HCV V, the record holder of the 2,073,500 shares of Issuer's Common Stock reported hereto. -9- Page 10 of 14 Item 3. If this statement is filed pursuant to Rule 13d-1(b) or (c), or 13d-2(b), check whether the person filing is a: Inapplicable. Item 4. Ownership. (a) Amount Beneficially Owned: As of December 31, 1998, HCV V and HCP V beneficially owned 2,073,500 Shares of Issuer's Common Stock; Dr. Cavanaugh beneficially owned 2,217,037 Shares of the Issuer's Securities, consisting of 2,075,821 Shares of Issuer's Common Stock and immediately exercisable warrants to purchase 141,216 Shares of Issuer's Common Stock(2); Mr. Werner beneficially owned 2,219,575 Shares of Issuer's Securities, consisting of 2,078,359 Shares of Issuer's Common Stock and immediately exercisable warrants to purchase 141,216 Shares of Issuer's Common Stock(2); Messrs. Littlechild and Crouse each beneficially owned 2,214,716 Shares of Issuer's Securities, consisting of 2,073,500 Shares of Issuer's Common Stock and immediately exercisable warrants to purchase 141,216 Shares of Issuer's Common Stock(2); and Mr. Leschly beneficially owned 2,073,500 Shares of Issuer's Common Stock. (b) Percent of Class: As of December 31, 1998: the 2,073,500 Shares of Issuer's Securities beneficially owned by each of HCV V, HCP V and Mr. Leschly constitute 9.3% of Issuer's Shares outstanding; the 2,214,716 Shares of Issuer's Securities beneficially owned by Messrs. Crouse and Littlechild constitute 9.9% of Issuer's Shares outstanding; the 2,217,037 Shares of Issuer's Securities beneficially owned by Dr. Cavanaugh constitute 9.9% of Issuer's Shares outstanding; and the 2,219,575 Shares of Issuer's Securities beneficially owned by Mr. Werner constitute 9.9% of Issuer's Shares outstanding. - -------- (2) The immediately exercisable warrants to purchase (i) 102,319 Shares of Issuer's Common Stock are held by HealthCare Ventures I, L.P. ("HCV I"), of which HealthCare Partners I, L.P. ("HCP I") is a general partner and (ii) 38,897 Shares of Issuer's Common Stock held by HealthCare Ventures II, L.P. ("HCV II"), of which HealthCare Partners II L.P. ("HCP II") is a general partner (collectively, the "Warrants"). Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are general partners of each of HCP I and HCP II. The exercise price of such Warrants is $8.00 per share. -10- Page 11 of 14 (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote: Dr. Cavanaugh has the sole power to vote or direct the vote of the 2,321 Shares of Issuer's Common Stock beneficially owned by him. Mr. Werner has the sole power to vote or direct the vote of the 4,859 Shares of Issuer's Common Stock beneficially owned by him. (ii) shared power to vote or to direct the vote: HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to vote or direct the vote of those Shares owned by HCV V.(3) (iii) sole power to dispose or to direct the disposition of: Dr. Cavanaugh has the sole power to dispose of or direct the disposition of the 2,321 Shares of Issuer's Common Stock beneficially owned by him. Mr. Werner has the sole power to vote or direct the vote of the 4,859 Shares of Issuer's Common Stock beneficially owned by him. (iv) shared power to dispose of or to direct the disposition of: HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to vote or direct the vote of those Shares owned by HCV V.(4) - ------- (3) Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse share the power to vote or direct the vote of the Shares of Issuer's Common Stock underlying the warrants held by HCV I and HCV II. (4) Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse share the power to vote or direct the vote of the Shares of Issuer's Common Stock underlying the warrants held by HCV I and HCV II. -11- Page 12 of 14 Item 5. Ownership of Five Percent or less of a Class: Inapplicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person: Inapplicable. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company: Inapplicable. Item 8. Identification and Classification of Members of the Group: Inapplicable. Item 9. Notice of Dissolution of Group: Inapplicable. Item 10. Certification: Inapplicable. -12- Page 13 of 14 SIGNATURES After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated: February 12, 1999 HealthCare Ventures V, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners V, L.P., By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Partners V, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 By: * Princeton, New Jersey ------------------------------- James H. Cavanaugh, Ph.D. Dated: February 12, 1999 By: * Princeton, New Jersey ------------------------------- Harold R. Werner Dated: February 12, 1999 By: * Cambridge, Massachusetts ------------------------------- John W. Littlechild Dated: February 12, 1999 By: * Princeton, New Jersey ------------------------------- William Crouse Dated: February 12, 1999 By: * Cambridge, Massachusetts ------------------------------- Mark Leschly -------------------------- *Signed by Jeffrey Steinberg as Attorney-in-Fact pursuant to the Power of Attorney filed previously and incorporated herein by reference. -13- Page 14 of 14 EXHIBIT A AGREEMENT JOINT FILING OF SCHEDULE 13G The undersigned hereby agree to jointly prepare and file with regulatory authorities a Schedule 13G and any future amendments thereto reporting each of the undersigned's ownership of securities of Magainin Pharmaceuticals, Inc. and hereby affirm that such Schedule 13G is being filed on behalf of each of the undersigned. Dated: February 12, 1999 HealthCare Ventures V, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners V, L.P., By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Partners V, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 By: * Princeton, New Jersey -------------------------------- James H. Cavanaugh, Ph.D. Dated: February 12, 1999 By: * Princeton, New Jersey -------------------------------- Harold R. Werner Dated: February 12, 1999 By: * Cambridge, Massachusetts -------------------------------- John W. Littlechild Dated: February 12, 1999 By: * Princeton, New Jersey -------------------------------- William Crouse Dated: February 12, 1999 By: * Cambridge, Massachusetts -------------------------------- Mark Leschly - ------------------- *Signed by Jeffrey Steinberg as Attorney-in-Fact -----END PRIVACY-ENHANCED MESSAGE-----